Stefan Mendt

Bioinformatics, M. Sc.

Center for Space Medicine and Extreme Environments Berlin
Charité Cross Over
Charitéplatz 1 
10117 Berlin

Email Me
+49 (0)30 450 528 519

During the bioinformatic study at the Department of Mathematics and Computer Science at Freie Universität Berlin, Stefan Mendt joined the group Physiology in Space and Extreme Environments as student assistant and completed a research internship on modeling circadian rhythms in humans. In 2012 Mr. Mendt wrote his Master’s thesis at Center for Space Medicine and Extreme Environments Berlin (ZWMB) about the effect of long-term bed-rest on the circadian temperature rhythm.

Since 2012 as doctoral student of Prof. Gunga, Mr. Mendt has been working on his thesis “Circadian core body temperature rhythm before during and after long-term space flights”. As research associate at the Charité – Universitätsmedizin Berlin since 2015, he also holds various courses in human physiology for bioinformatics and medicine students.

Research focus

  • Effects of extreme environmental conditions (in space or on Earth) on human circadian rhythms

Mr. Mendt is currently working on physiological data of

  • farmers in Sub-Saharan Africa
  • overwinterers of the French–Italian Concordia Research Station in Antarctica
  • astronauts from ESA/DLR project Circadian Rhythms
  • healthy participants underwent 60 days of head-down tilt bedrest
  • cardiac arrest patients after mild therapeutic hypothermia

Additionally,  he supports the group in the processing and analysis of various types of physiological data (temperature, cognition, body composition, ECG, HRV, EEG, etc.) generating from the numerous research projects of the group. His favorite tool is R, a software environment for statistical computing and graphics.

Research Projects

Co-Investigator

  • DFG: Climate change, heat stress and their impact on health and work capacity (within the DFG Research Unit 2936: Climate change and health in Sub-Saharan Africa) (PI: Hanns-Christian Gunga)
  • ESA/DLR: Evaluation of circadian rhythm alterations by functional biomarkers during winter over at Concordia (PI: Martina Anna Maggioni)
  • ESA/DLR: Circadian Rhythms: Core temperature and circadian rhythms in humans during long-term spaceflights (PI: Hanns-Christian Gunga)

Publications

2021

Merati G, Bonato M, Agnello L, Grevers D, Gunga H-C, Mendt S, Maggioni MA Occupational Disorders, Daily Workload, and Fitness Levels Among Fitness and Swimming Instructors Frontiers in Public Health

Mendt S, Brauns K, Friedl-Werner A, Belavỳ DL, Steinach M, Schlabs T, Werner A, Gunga H-C, Stahn AC Long-term Bed Rest Delays the Circadian Phase of Core Body Temperature Frontiers in Physiology

Mendt S, Gunga HC, Felsenberg D, Belavỳ DL, Steinach M, Stahn AC Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest npj Microgravity

2020

Maggioni MA, Merati G, Castiglioni P, Mendt S, Gunga H-C, Stahn AC Reduced vagal modulations of heart rate during overwintering in Antarctica Scientific Reports

2018

Martina MA, Castiglioni P, Merati G, Brauns K, Gunga H-C, Mendt S, Opatz OS, Rundfeldt LC, Steinach M, Werner A, Stahn A High-Intensity Exercise Mitigates Cardiovascular Deconditioning During Long-Duration Bed Rest Frontiers in Physiology

Masatli Z, Nordine N, Martina M.A, Mendt S, Hilmer B, Brauns K, Werner A, Schwarz A, Habazettl H, Gunga H-C, Opatz O Gender-Specific Cardiovascular Reactions to +Gz Interval Training on a Short Arm Human Centrifuge Frontiers in Physiology

2017

Stahn A, Werner A, Opatz O, Maggioni MA, Steinach M, Weller von Ahlefeld V, Moore A, Crucian BE, Smith SM, Zwart SR, Schlabs T, Mendt S, Trippel T, Koralewski E, Koch J, Choukèr A, Reitz G, Shang P, Röcker L, Kirsch KA, Gunga HC Increased core body temperature in astronauts during long-duration space missions Scientific Reports

2016

Mendt S, Maggioni MA, Nordine M, Steinach M, Opatz O, Belavý D, Felsenberg D, Koch J, Shang P , Gunga H-C, Stahn A Circadian rhythms in bed rest: Monitoring core body temperature via heat-flux approach is superior to skin surface temperature Chronobiology International

Steinach M, Kohlberg E, Maggioni MA, Mendt S, Opatz O, Stahn A, Gunga H-C Sleep Quality Changes during Overwintering at the German Antarctic Stations Neumayer II and III: The Gender Factor PloS One

2015

Steinach M, Kohlberg E, Maggioni MA, Mendt S, Opatz O, Stahn A, Tiedemann J, Gunga H-C Changes of 25-OH-Vitamin D during Overwintering at the German Antarctic Stations Neumayer II and III PloS One

Nordine N, Maggioni MA, Stahn A, Mendt S, Brauns K, Gunga H-C, Habazettl H, Nitsche A, Opatz O Form influences function: Anthropometry and orthostatic stability during sustained acceleration in a short arm Human centrifuge Acta Astronautica

Awards

  • 2014 Second Poster Prize for Monitoring Circadian Rhythm of Core Body Temperature Using the Heat-Flux Approach is Superior to Skin Surface Temperature Recordings at the 52nd Annual Scientific Meeting of Deutsche Gesellschaft für Luft- und Raumfahrtmedizin (DGLRM) e.V.
  • 2011 Nathan Zuntz Scholarship (1 year)